Media Releases
Ready-to-Use Devices for Optimizing Bioprocesses with Integrated Sensors
Gernot Thomas John, Athanas Apostolidis, and Christian Krause;
BioProcess International Vol.7 No.7: Yearbook 2009
Real-Time Bioprocess Monitoring in Shake Flasks, Spinner Flasks and Microtiter Plates
Bioprocess fermentors are typically equipped with real-time monitoring devices such as temperature, pH, oxygen, or even viable cell density. The advantages of online over off-line measurements are easiness of use, timely results, and the possibility of immediate responses to the measured value. By contrast with the well-equipped fermentors used for production, the disposables used in bioprocess development have lacked such online measurement devices so far.
Quality Assessment in 3D Cultures of Disc-Chondrocytes
Karin Benz and Jürgen Mollenhauer;
BioProcess International Vol.6 No.11
Optosensoric Online Monitoring of Oxygen and pH Kinetics
Autologous chondrocyte transplantation is a modern experimental therapy for treatment of degenerative intervertebral disc diseases. Several studies with animal models have shown that transplantation of cultivated autologous chondrocytes can delay progression of disc degeneration. A few products based on human autologous condrocytes are already on the market. Repair of disc damages with grafted chondrocytes appears feasible in the near future. So chances are growing for clinical applications meant for restoration of original disc functions. As a result, optimization and standardization of the individual steps of the laborious therapeutic approach gain even more importance.
Single-Use Containers Demand Single-Use Sensors
Gernot Thomas John and Sarina Arain;
BioProcess International Vo. 6 No. 7: Yearbook 2008
Why Chemical Optical Sensors from PreSens Precision Sensing Are an Excellent Option
Demand for single-use bioprocess systemsin the biotech and pharmaceutical industry has increased signigicantly in recent years. Among other reasons- such as operations, sourcing, and validation - their lower initial investment capital makes disposable systems very attractive for the pharmaceutical industry. When Wave Viotech introduced the firs wave-action reactor/mixer, it was seen by some as the start of single-use technology. Once containers become single-use, all other parts of the manufacturing process ideally have to follow the same principle. These include coneectors, tubings, pumps, ultrafiltration/diafiltration (UF/DF) devices, and last but not least: sensors.
Process Monitoring in Suspension-Adapted CHO Cell Cultures
Harry Abts and Sarina Arain;
BioProcess International Vol. 6 No. 1
Noninvasive Online Detection of pH and Oxygen
Suspension-adapted Chinese hamster ovary cell (CHO-S) cultures are widely used in biotechnological production of recombinant proteins. In fact, such special cell lines have become the standard for this type of biopharmaceutical production. The reasons for that include their fast reproduction, high protein expression rate compared with other eukaryotic cells and, above all, the glycosylation patterns generated by the cells. Efficient production of correctly processed proteins requires optimized cultivation parameters.
