Watch tutorials, webinars and informative videos about PreSens optical sensor systems.
Find Publications and Information about Your Optical Sensor System
Whether it is general information or detailed, application based data on optical sensors you are looking for, in our collection of publications, sensor basics and FAQs you will find what you need. Furthermore, short tutorial videos and our instruction manuals will help you with handling your sensor system.
Online Monitoring of C. glutamicum Culture in Ultra Yield® Flasks: SFR vario Used with Only Slightly Translucent Shake Flasks
C. Ude and G. T. John
PreSens Precision Sensing GmbH, Regensburg, Germany
In this study we analyzed, if slightly translucent polypropylene shake flasks can be used for optical measurements and especially optical biomass monitoring with the SFR vario. As…
Download PDFWhy It Is Important to Measure Different Parameters Online in Shake Flasks: SFR vario Measures O2, OUR, pH and Biomass Online
R. W. Maschke1, G. T. John2, and D. Eibl1
1 ZHAW Zurich University of Applied Sciences, School of Life Sciences and Facility Management, Wädenswil, Switzerland
2PreSens Precision Sensing GmbH, Regensburg, Germany
Optical sensors enable monitoring and controlling important culture parameters even at shake flask scale. In this short report we show an example of multiparameter monitoring with…
Download PDFIn situ Remediation of Contaminated Groundwater: VisiSens TD used to study release of groundwater remedial amendments from well screens under flow-through conditions
Seagren E.A., Waypa A.
Department of Civil, Environmental, and Geospatial Engineering, Michigan Technological University, USA
This application note shows how the VisiSens imaging technology can be used to visualize and quantify the release of groundwater remedial amendments from unpumped wells under…
Download PDFFungal Metabolite Screening Inside a Microfluidic Bioreactor: pH Measurements in Plant Cell Culture with pH-1 SMA HP5
L. Schmidt-Speicher1, C. Metzger2, F. Kinn1, B. Bailer3, Dr R. Ahrens1
1Karlsruhe Institute of Technology, Institute of Microstructure Technology, Eggenstein-Leopoldshafen, Germany
2Karlsruhe Institute of Technology, Botanical Institute, Karlsruhe, Germany
3Hochschule Biberach, Biberach, Germany
As sessile organisms, plants cannot easily circumvent stressors by relocating. To evaluate the quality and quantity of abiotic and biotic stresses experienced, plants have evolved…
Download PDFO2, pH and CO2 Monitoring in Microfluidic Mammalian Cell Culture: Cultivated Meat Bioprocess Optimization with SensorPlugs
Vasa Radonic, Ivana Podunavac, Mila Djisalov, Teodora Knezic, Ivana Gadjanski
BioSense Institute, Novi Sad, Serbia
We tested the efficacy of PreSens SensorPlugs for monitoring mammalian cell culturing processes in microfluidic bioreactors (MBs) with integrated sensors. MRC-5 fibroblasts (ATCC®…
Download PDFCultivated Meat Bioprocess Optimization: O2, pH and CO2 Monitoring in E. coli Culture with PreSens SensorPlugs
Vasa Radonic, Ivana Podunavac, Mila Djisalov, Teodora Knezic, Ivana Gadjanski
BioSense Institute, Novi Sad, Serbia
We tested the efficacy of PreSens SensorPlugs for monitoring bacterial cultures in microfluidic bioreactors (MBs), which is important in the context of monitoring potential…
Download PDFA Microfluidic Platform for Real-Time Non-Invasive Monitoring of Microglia Polarization: Application of novel optical SensorPlugs for microfluidics
Elifsu Polatli1,2, Alperen Yilmaz1,3, Resul Özbilgiç1,2, Íbrahim H. Erbay1,2, Duygu Sağ1,2,4, Sinan Güven1,2,4,*
1Izmir Biomedicine and Genome Center, Izmir, Turkey
2Dokuz Eylul University, Izmir International Biomedicine and Genome Institute, Izmir, Turkey
3Ankara University, Department of Biomedical Engineering, Izmir, Turkey
4Dokuz Eylul University, School of Medicine, Izmir, Turkey
*Corresponding author: sinan.guven@ibg.edu.tr
In this study, we hypothesized that sensor systems can be utilized for non-invasive real-time monitoring in microglia metabolism to further elucidate the polarization levels…
Download PDFInterpreting SFR vario Online Data Gathered in Plant Cell Suspension Culture: Characterization of plant cell lines for successful production processes
R. W. Maschke1, B. Pretzner2, G. T. John3, D. Eibl1
1Zurich University of Applied Sciences, Institute of Chemistry and Biotechnology, Wädenswil, Switzerland
2Werum IT Solutions GmbH, Vienna, Austria
3PreSens Precision Sensing GmbH, Regensburg, Germany
Characterizing CHO Cell Lines with SFR vario: What online measured data can tell about your cell culture
R. W. Maschke1, B. Pretzner2, G. T. John3, D. Eibl1
1Zurich University of Applied Sciences, Institute of Chemistry and Biotechnology, Wädenswil, Switzerland
2Werum IT Solutions GmbH, Vienna, Austria
3PreSens Precision Sensing GmbH, Regensburg, Germany
Cell Culture Monitoring in Stirred-Tank Bioreactor with Optical pH Sensors: Novel pH probe and pH sensor spots used in long-term cell culture
Melissa Hill1, Greg Laslo1, Marcelo Kern1, Sayantan Bose1, Christian Krause2
1GlaxoSmithKline, King of Prussia, PA, USA
2PreSens Precision Sensing GmbH, Regensburg, Germany
We used PreSens novel autoclavable optical sensor spots, as well as a novel pH probe, for online cell culture monitoring. Optical measurements were compared to reference data from…
Download PDFIntegration of Chemical-Optical Oxygen and pH Sensors in Existing Control Units: Cultivation monitoring in a glass bioreactor system with subsequently integrated sensor spots
Cedric Schirmer1, Vivian Ott1, Gernot T. John2, Dieter Eibl1
1Zurich University of Applied Sciences, School of Life Sciences and Facility Management, Institute of Chemistry and Biotechnology, Wädenswil, Switzerland
2PreSens Precision Sensing GmbH, Regensburg, Germany
The use of chemical-optical sensors for monitoring a cultivation using bioreactors with an already existing control unit requires the input of additional measuring signals. For…
Download PDFAdhesive Cell Growth and Microscopy on O2 and pH Sensor Foils: Impact of coating on the adhesion of cells upon VisiSens™ sensor foils SF-RPSu4 and SF-HP5R
C. Schmittlein1, R. J. Meier2, G. Liebsch2, J. Wegener1,3
1Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, Germany
2PreSens Precision Sensing GmbH, Regensburg, Germany
3Fraunhofer Research Institution for Microsystems and Solid State Technologies (EMFT), Regensburg, Germany
Suspension of Madin-Darby Canine Kidney cells (MDCK-II) were plated on VisiSens™ sensor foils SF-RPSu4 (O2) and SF-HP5R (pH) that were integrated in regular Petri dishes. Cell…
Download PDFNon-invasive pH Monitoring in Anaerobic Clostridium Culture: Evaluation of the pH Sensor Spot SP-LG1 in Low pH Range
Nikola Naschitzki
Beuth University of Applied Sciences, Berlin, Germany
A prototype pH sensor spot type LG1 was integrated in a closed, gas-tight culture bottle for monitoring an anaerobic cultivation of Clostridium acetobutylicum. The sensor allowed…
Download PDFImaging of pH and pO2 on Irradiated Fibroblasts and Oral Squamous Carcinoma Cells: Dual read-out of pH and pO2 in 96 well plates with VisiSens TD
Yvonne Reinders1, Robert J. Meier2, Gregor Liebsch2 and Frank Haubner3
1Department of Plastic, Aesthetic, Hand & Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany
2PreSens Precision Sensing GmbH, Regensburg, Germany
3Department of Otorhinolaryngology, Ludwig-Maximilians-University Munich, Munich, Germany
Improving Culture Conditions of Antibody-Producing Yeast: Use of Deep Well SensorDishes® for pH and DO Monitoring
Lotta Kirjavainen and Alexander Frey
Aalto University, Finland
Reliable screening set-ups are the key to rapid identification of genetic modifications or changes of cultivation conditions improving strain performance. Moreover, online…
Download PDFO2, pH and CO2 Dynamics in Salt Marsh Tidal Ponds: Investigations under Different Light Regimes with Optical Profiling Microsensors and an Automated Micromanipulator
Ketil Koop-Jakobsen1 and Martin Gutbrod2
1University of Bremen, MARUM - Center for Marine Environmental Scienes, Bremen, Germany
2PreSens Precision Sensing GmbH, Regensburg, Germany
Salt marsh ponds are extreme environments characterized by high microbial activity and strong biogeochemical gradients at the sediment water interface. In this study, we…
Download PDFQuality Assessment of Primary Human Keratinocyte Cultures: Online Measurement of Oxygen and pH with the SDR SensorDish® Reader
V. Lorenz, B. Roski, A. Hermann, and H. F. Abts
Celonic GmbH, Jülich, Germany
The SDR SensorDish® Reader allows non-invasive analysis of dissolved oxygen (DO) and pH in multiwell plates. In this sutdy the sensitivity of the monitoring device was tested in…
Download PDFThe Application of the SFR Shake Flask Reader in Teaching at the Esslingen University of Applied Sciences: Non-invasive Measurements of Dissolved Oxygen and pH in Shake Flasks within the Framework of Practical Courses and Student Projects
A. Komitakis, K. Schatz, M. Hoß, R. Biener
Department Biotechnology, Esslingen University of Applied Sciences, Germany
Dissolved oxygen (DO) and pH are key parameters for microbial fermentations and cell cultures. The importance of DO and pH for bioprocesses as well as methods for their measurement…
Download PDFSimultaneous pH, CO2 and O2 Measurements in Algae Photobioreactor: pH Flow-Through Cells successfully evaluated for later use in the International Space Station ISS
Gisela Detrell and Jochen Keppler
Institute of Space Systems, University of Stuttgart, Germany
At the Institute of Space Systems several experiments with algae photobioreactors were conducted, in order to design a system to be tested in the International Space Station in…
Download PDFBenthic Disturbance-Recovery Dynamics in a Changing Coastal Ocean: Imaging the effects of terrestrial sediment deposits on intertidal sandflat pH and O2 with VisiSens technology
Kay Vopel, Aysha Hohaia, Chris Pook, and John Robertson
Institute for Applied Ecology New Zealand, Auckland University of Technology, New Zealand
Changes in climate and land use increase the supply of terrestrial sediment to coastal water worldwide but the effects of this increase on ecosystem functioning are not well known.…
Download PDFImaging Rhizosphere pH and CO2 Dynamics: Plant Root - Soil Interactions Quantified with Prototype VisiSens Systems
S. Blossfeld1, C. M. Schreiber2, G. Liebsch3, A. J. Kuhn1, and P. Hinsinger2
1Forschungszentrum Jülich GmbH, Institute of Bio- and Geosciences, IBG-2: Plant sciences, Jülich, Germany
2INRA, UMR Eco&Sol, Montpellier, France
3PreSens Precision Sensing GmbH, Regensburg, Germany
Prototype VisiSens™ devices for pH & CO2 imaging were used to perform continuous and highly resolved measurements in rhizobox systems. pH was measured around durum wheat roots…
Download PDFImmobilized Plant Cells - From DSMZ to the Customer: VisiSens technology used to detect metabolic activities of immobilized plant cells during simulated cell transport in a closed system
Nicole Brinkmann, Martina Westphal, Elke Heine-Dobbernack, and Martin Schumacher
Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
The DSMZ is one of the largest biological resource centers worldwide. Its collections currently comprise almost 40,000 items, including about 700 undifferentiated plant cell lines.…
Download PDFDiffusive / Dispersive Reaction Fronts in Groundwater: 2D visualization of oxygen and pH using the VisiSens imaging system to study Fe2+ oxidation under flow-through conditions
Christina Haberer1, Muhammad Muniruzzaman1, Massimo Rolle1,2, and Peter Grathwohl1
1Department of Geosciences, University of Tübingen, Germany
2Department of Civil and Environmental Engineering, Stanford University, USA
Quasi 2D flow-through experiments were performed in heterogeneous porous media to study the oxidation of ferrous iron in groundwater using the VisiSens™ imaging system for oxygen…
Download PDFO2, CO2 and pH Dynamics in the Capillary Fringe: VisiSens combined with an automated linear positioning system provides complete analyte maps
M. Wagner, N. Hack, G. Abbt-Braun, and H. Horn
Chair of Water Chemistry and Water Technology, Engler-Bunte-Institut, Karlsruhe Institute of Technology, Germany
We investigated the biochemical transformation potential in the capillary fringe (CF) by measuring the distribution of dissolved gases and the pH value. Therefore, we combined the…
Download PDFOptical pH Surveillance in a Microfluidic System for Cell Culture: Evaluation of VisiSens pH sensor foils integrated in microfluidic systems
A. Schopf1,2, C. Boehler1,2, M Asplund1,2
1Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany
2Brain Tools Cluster of Excellence, University of Freiburg, Germany
pH surveillance within microfluidic systems is a challenging problem. Liquid quantities available for measurement are limited and also relatively inaccessible within the…
Download PDFDevelopment of a Partly Controllable System at Shake Flask Scale: Enhanced data quality obtained from fed-batch shake flask cultivation by minimizing disturbance variables monitored by the SFR
Christian Klinger, Sylvia Baumann, Robert Puskeiler, and Alexander Jockwer
Roche Diagnostics GmbH, Pharma Biotech Production and Development, Penzberg, Germany
The main objective of this study was to develop an easy to handle and partly controllable process cultivation system at shake flask scale. First, it was investigated how…
Download PDFOnline Monitoring of Glucose, pH, and DO in Shake Flask Culture: Novel Glucose Sensor Used in Combination with the SFR Shake Flask Reader
I. Bauer1, G. T. John2, S. Spichiger3, and U. E. Spichiger-Keller3
1Zurich University of Applied Sciences, School of Life Sciences and Facility Management, Institute of Biotechnology, Biochemical Engineering and Cell Cultivation Technique, Waedenswil, Switzerland
2PreSens Precision Sensing GmbH, Regensburg, Germany
3C-CIT AG, Waedenswil, Switzerland
A new single-use glucose sensor in combination with chemical optical oxygen and pH sensors was used for online monitoring of CHO cell culture in shake flasks. During the whole…
Download PDFDevelopment of a Shaken Scale-Down Model: Characterization of Critical Parameters in Bioprocess Development
Holger Kley, Jan Kreuzmann, Caroline Schuster, and Robert Puskeiler
Roche Diagnostics GmbH, Pharma Biotech Production and Development, Penzberg, Germany
A shaken scale-down model at approx. 0.1 L scale for a previously established stirred-tank model at 2 L scale was developed. In the shaken scale-down model online monitoring of pH…
Download PDFCharacterization of Microbial Growth Profiles: Online detection of oxygen and pH during culture in shake flasks
Konstantin Schneider1, Verena Schütz1, Gernot Thomas John2 and Elmar Heinzle1
1Biochemical Engineering Institute, Saarland University, 66123 Saarbrücken, Germany
2PreSens Precision Sensing GmbH, 93053 Regensburg, Germany
Shake flasks are the most commonly used cultivation systems for process and media optimization, screening for new products and strains as well as for the supply of inoculum for…
Download PDFInsect Cell Cultivation in Orbitally Shaken Flasks with Sensors: Oxygen mass transfer in insect cell-based high cell density cultivations
N. Riesen, C. Ries, R. Eibl, D. Eibl
Zurich University of Applied Sciences, School of Life Sciences and Facility Managment, Institute of Biotechnology, Biochemical Engineering and Cell Cultivation Techniques, Wädenswil, Switzerland
Insect cell-based processes have become increasingly influential for tool protein and Virus-like Particle (VLP) vaccine productions over the last years. At small scale insect cells…
Download PDFNew Device for Biomass Monitoring in Shake Flask Culture: Development of an analytical unit based on the SFR Shake Flask Reader
J. Schmidt-Hager1, C. Ude1, M. Findeis2, G. T. John2, T. Scheper1, and S. Beutel1
1Institute of Technical Chemistry, Leibniz University of Hanover, Germany
2PreSens Precision Sensing GmbH, Regensburg, Germany
We developed a novel system for online biomass measurement in shake flasks based on near 360° scattered light detection. The optosensoric components were combined with the…
Download PDFOnline Monitoring of S. cerevisiae Culture with the SFR vario: New online biomass data is in very good accordance with offline measurements
Dylan Haskew1, Gernot T. John2, and Dogan Ornek1
1Upstream Process Development, FUJIFILM Diosynth Biotechnologies U. S. A., Inc., US
2PreSens Precision Sensing GmbH, Germany
In order to investigate a model process with Saccharomyces cerevisiae the new SFR vario shake flask reader was used to monitor O2, OUR, pH, and biomass online inside 2 L shake…
Download PDFpH Monitoring in Dairy Starter Cultures: Characterization of acid production with optical sensors in microtiter plates
G. T. John1, D. Goelling2, I. Klimant3, H. Schneider2, and E. Heinzle1
1Technical Biochemistry, Saarland University, Saarbrücken, Germany
2Danisco Cultor Niebüll GmbH, Niebüll, Germany
3Institute for Analytical Chemistry, Chemo- and Biosensors, University Regensburg, Regensburg, Germany
Starter cultures are used to guarantee good and reproducible quality of dairy products. In this study an easy-to-use method to screen a large number of inoculum cultures as quality…
Download PDFOxygen and pH Monitoring in Deep Well OxoDishes® and HydroDishes®: Assessing optimal growth conditions for shaken yeast culture
Thomas Grimm
BIOWORX, Berlin, Germany
In this study different yeast cultivations in deep well OxoDishes® and HydroDishes® were examined. Cultivations were carried out at varying volumes to assess optimal growth…
Download PDFCo-Cultures of Caco-2 cells and E.coli: Optosensoric online monitoring of O2 uptake and extracellular acidification
Martin Brischwein and Daniel Grundl
Heinz-Nixdorf-Lehrstuhl für Medizinische Elektronik, TU München
Oligogalacturonic acids (OGAs), obtained by hydrolysis of pectin, are known to inhibit the adhesion of pathogenic bacteria on intestinal cells and thus to prevent infectious…
Download PDFProcess Monitoring in Suspension-Adapted CHO Cell Cultures: Non-invasive online detection of pH and oxygen
Harry Abts1 and Sarina Arain2
1Celonic GmbH, Karl-Heinz-Beckurts-Straße 13, Jülich, Germany
2PreSens GmbH, Josef-Engert-Str. 11, 93053 Regensburg, Germany
Online detection of oxygen and pH by using SDR at a small-scale can be used as a basis for latter cultivation in large-scale bioreactors to detect optimal growth conditions.…
Download PDFDesign of Experiment (DoE) for Fed-batch Process Development in Shaken Cultures: Determination of reproducibility and scalability in Escherichia coli cultures grown under fed-batch conditions using SensorDishes® and Sensor Flasks
F. Glauche, N. Cruz, A. Knepper, M. Föllmer, S. Junne, P. Neubauer
Laboratory of Bioprocess Engineering, Department of Biotechnology, TU Berlin, Germany
When designing a recombinant protein production process, a high number of parallel cultivations need to be carried out. This is mostly performed using batch cultures in shake…
Download PDF3D Cultures of Disc-Chondrocytes: Optosensoric Online Monitoring of Oxygen and pH Kinetics
Karin Benz and Jürgen Mollenhauer
Regenerative Medizin II, NMI Reutlingen, Markwiesenstraße 55, 72770 Reutlingen, Germany
Hydrogel-based 3D cell culture systems offer particular advantages for tissue-engineering in cell-based therapy for disc-degeneration. However, light microscopical control of both…
Download PDFSimultaneous Monitoring of pH and Oxygenation in Microvolumes of Blood: Fiber optical pH microsensors and miniature broad range spectrophotometry advance blood function analysis
Michael Oellermann, Hans-Otto Pörtner, and Felix C. Mark
Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany
The implementation of a pH microsensor and a miniature broad range spectrophotometer in a gas diffusion chamber facilitated the pH dependent analysis of blood oxygen binding…
Download PDFpH Monitoring of Urine and Tumor Microenvironments in Rats: High Spatial Resolution Measurements Controlled with the Manual Micromanipulator
T. Kiskova1, Z. Steffekova2, M. Karasova2, N. Kokosova1
1P. J. Šafárik University in Košice, Faculty of Sciences, Košice, Slovakia
2University of Veterinary Medicine and Pharmacy in Košice, Slovakia
The aim of our study was to monitor pH of urine samples (< 100 µL) and of tumor microenvironments of anesthetized rats in a minimal invasive way. The small urine volumes of rats or…
Download PDFpH Regulation for a Liver Cell Bioreactor: Prototype development with a chemical optical pH flow-through cell
Marco Decker
Fachhochschule für Technik und Wirtschaft Berlin (FHTW), Berlin
An important aspect of efficient liver cell bioreactors is the automated regulation of physio-chemical culture parameters. The present study describes the development of the first…
Download PDFAssessing the Impact of pH Fluxes between the Sediment-Water Interface on the Overlaying Water Column off Namibia: Spatial variability of pore water pH investigated with single-use flow-through cells pH
Anita Flohr, Tim Rixen, Matthias Birkicht
Leibniz Center for Tropical Marine Ecology, Bremen, Germany
Eastern boundary upwelling systems, such as the Benguela upwelling system off the south west African coast, are characterized by high concentrations of dissolved inorganic carbon…
Download PDFValidation Study of the Optrode Dual™: Oxygen and pH Measurements in a Single-Use Bioreactor with Integrated Optical Sensors Using a Conventional Controller
Stephan Kaiser & Dieter Eibl
Institute for Biotechnology, Department of Life Sciences and Facility Management, Zurich University of Applied Sciences, Switzerland
The Optrode Dual™ converts measurement data of optical sensors into electrochemical signals (ECS) which can be transferred to controller units for bioreactors. The user can record…
Download PDFOptrode Dual Connects Single-Use Bioreactors to Conventional Controllers: Monitoring of CHO Cell Cultivation with Chemical Optical Sensors
Stephan Kaiser, Franziska Fietz, Nina Steiger, and Dieter Eibl
Institute for Biotechnology, Department of Life Sciences and Facility Management, Zurich University of Applied Sciences, Switzerland
The Optrode Dual™ prototype has been applied for measurements in suspension adapted CHO cell culture. The transmitter converts the reading of chemical optical sensors integrated in…
Download PDFOnline pH and DO Measurements in Microcarrier-Based hMSC Cultivations: Culture monitoring with sensor spots integrated in single-use spinner flasks
V. Jossen1, C. Schirmaier1, G. T. John2, D. Eibl1, and R. Eibl1
1Zurich University of Applied Sciences, School of Life Sciences and Facility Management, Institute of Biotechnology, Wädenswil, Switzerland
2PreSens Precision Sensing GmbH, Regensburg, Germany
Spinner flasks are often used for microcarrier-based cultivations of human mesenchymal stem cells (hMSCs). Normally, they are not equipped with pH and dissolved oxygen (DO) probes.…
Download PDFAdvanced Respirometry with Chemical Optical Sensor Spots: Non-invasive Tracking of Oxygen, Carbon Dioxide and pH as Indicator for Nitrification Activity
Eva M. Gilbert, Susanne Lackner
Karlsruhe Institute of Technology (KIT), Engler-Bunte Institute, Water-Chemistry and Water Technology, Karlsruhe, Germany
Respirometry is an indirect way of measuring microbial activity, such as nitrification. The oxygen uptake is proportional to the substrate consumption - given by the stoichiometry…
Download PDFOnline pH Measurements in iTube pH Bioreactors: Evaluating the ITR iTube96Reader for Monitoring Insect Cell Culture Growth for Biopesticide Production
Ina Dittler1, Gernot T. John2, and Regine Eibl1
1Zurich University of Applied Sciences, School of Life Sciences and Faciltiy Management, Institute of Biotechnnology, Wädenswil, Switzerland
2PreSens Precision Sensing GmbH, Regensburg, Germany
In our experiments we tested TubeSpin50 bioreactors with integrated pH sensors (referred to as iTube pH bioreactors). We evaluated their suitability for growing Lymantria dispar…
Download PDFThe protective role of proton‑sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model
Koichi Sato, Ayaka Tobo, Chihiro Mogi, Masayuki Tobo, Nobuhiro Yamane, Masahiko Tosaka, Hideaki Tomura, Dong‑Soon Im & Fumikazu Okajima
Scientific Reports (2020) 10:17193
Continuous optical in-line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality
Mario Lederle, Mircea Tric, Tatjana Roth, Lina Schütte, Anke Rattenholl, Dirk Lütkemeyer, Stefan Wölfl, Tobias Werner, Philipp Wiedemann
Biotechnol. J. (2021) 16:2100088
Functional strain redundancy and persistent phage infection in Swiss hard cheese starter cultures
Vincent Somerville, Hélène Berthoud, Remo S. Schmidt, Hans-Peter Bachmann, Yi Hélène Meng, Pascal Fuchsmann, Ueli von Ah, Philipp Engel
The ISME Journal (2022) 16, 388-399
Acidic microenvironments Found in Cutaneous Leishmania Lesions Curtail NO-Dependent Antiparasitic Macrophage Activity
Linus Frick, Linda Hinterland, Kathrin Renner, Marion Vogl, Nathalie Babl, Simon Heckscher, Anna Weigert, Susanne Weiß, Joachin Gläsner, Raffaela Berger, Peter J. Oeffner, Katja Dettmer, Marina Kreutz, Valentin Schatz and Jonathan Jantsch
Front. Immunol. (2022) 13:789366
SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner
Lorenzo Moroni, Fulvio Barbaro, Florian Caiment, Orla Coleman, Sabine Costagliola, Giusy Di Conza, Lisa Elviri, Stefan Giselbrecht, Christian Krause, Carlos Mota, Marta Nazzari, Stephen R. Pennington, Annette Ringwald, Monica Sandri, Simon Thomas, James Waddington and Roberto Toni
Int. J. Mol. Sci. (2020), 21, 3648
Early pH Changes in Musculoskeletal Tissues upon Injury - Aerobic Catabolic Pathway Acitvity Linked to Inter-Individual Differences in Local pH
Julia C. Berkmann, Aaron X. Herrera Martin, Agnes Ellinghaus, Claudia Schlundt, Hanna Schell, Evi Lippens, Georg N. Duda, Serafeim Tsitsilonis and Katharina Schmidt-Bleek
Int. J. Mol. Sci. (2020), 21, 2513
HEK293 Cell-Based Bioprocess Development at Bench Scale by Means of Online Monitoring in Shake Flasks (RAMOS and SFR)
Tibor Anderlei, Michael V. Keebler, Jordi Joan Cairó, and Martí Lecina
In: Pörtner R. (eds) Animal Cell Biotechnology. Methods in Molecular Biology, vol 2095. Humana, New York, NY (2020) 83 - 103
Preparing for cell culture scale-out: establishing parity of bioreactor- and flask-expanded mesenchymal stromal cell cultures
Ruud Das, Rens Roosloot, Melissa van Pel, Koen Schepers, Marijn Driessen, Willem E. Fibbe, Joost Dick de Bruijn and Helene Roelofs
J Transl Med (2019) 17:241
Bioreactor-manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies
A. Vukasovic, M. A. Ashaghi, P. Kostesic, H. Quasnichka, C. Cozzolino, M. Pusic, L. Hails, N. Trainor, C. Krause, E. Figallo, G. Filardo, E. Kon, A. Wixmerten, D. Maticic, G. Pellegrini, W. Kafienah, D. Hudetz, T. Smith, I. Martin, A. Ivokovic, D. Wendt
Cell Proliferation (2019) 00:e12653
The choroid plexus sodium-biocarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH
H. L. Christensen, D. Barbuskaite, A. Rojek, H. Malte, I. B. Christensen, A. C. Füchtbauer, E.-M. Füchtbauer, T. Wang, J. Praetorius, H. H. Damkier
J Physiol 596.19 (2018) 4709-4728
Tomato plants rather than fertilizers drive microbial community structure in horticultural growing media
Oliver Grunert, Ana A. Robles-Aguilar, Emma Hernandez-Sanabria, Silvia D. Schrey, Dirk Reheul, Marie-Christine Van Labeke, Siegfried E. Vlaeminck, Tom G. L. Vandekerckhove, Mohamed Mysara, Pieter Monsieurs, Vicky M. Temperton, Nico Boon & Nicolai D. Jablonowski
Scientific Reports (2019) 9:9561
Application of an Online-Biomass Sensor in an Optical Multisensory Platform Prototype for Growth Monitoring of Biotechnical Relevant Microorganisms and Cell Lines in Single-Use Shake Flasks
Christian Ude, Jörg Schmidt-Hager, Michael Findeis, Gernot T. John, Thomas Scheper, Sascha Beutel
Sensors, 2014, 14, 17390 - 17405
Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids
Eva Gottfried, Sebastian Rogenhofer, Heidi Waibel, Leoni A. Kunz-Schughart, Albrecht Reichle, Monika Wehrstein, Alice Peuker, Katrin Peter, Gabi Hartmannsgruber, Reinhard Andreesen, Marina Kreutz
Cancer Chemother Pharmacol (2010)
Disentangling who is who during rhizosphere acidification in root interactions: combining fluorescence with optode techniques
Marc Faget, Stephan Blossfeld, Philipp von Gillhaussen, Ulrich Schurr, and Vicky M. Temperton
Frontiers in Plant Science, Functional Plant Ecology, Vol. 4, Article 392, 2013
Miniature bioreactors for automated high-throughput bioprocess design (HTBD): reproducibility of parallel fed-batch cultivations with Escherichia coli
Robert Puskeiler, Andreas Kusterer, Gernot T. John, and Dirk Weuster-Botz
Biotechnol. Appl. Biochem., 2005, 42, pp. 227 - 235
Mikrotiterplatten-Reaktoren mit integrierten pH-Sensoren und Autodisplay in E.coli zur evolutiven Enzymentwicklung
E. Heinzle, S. Weiß, O. Wolfbeis, S. Arain, I. Klimant, G. John, C. Krause, T. Räbiger, G. Müller, H. Waltenberger, J. Josse, E. Schultheiss
Biokatalyse transkript Sonderband 2003
Entwicklung von innovativen Mikrotiterplattenreaktoren zur Bewertung des Abbaus und der Toxizität neuer Wirkstoffe auf Basis von Mikrosomen und Säugerzellen
Prof. Dr. Elmar Heinzle, Rahul Ravi Deshpande, Dr. Udo Bock, Dr. Gernot John, Dr. Christian Krause, Dr. Günther Müller, Dr. Harald Waltenberger, Dr. Ruth Maas
Biokatalyse transkript Sonderband 2003