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Online Dissolved Oxygen Monitoring in Disposable Bioreactors
DO Nice Port
This port with integrated oxygen sensor is for customized application in flexible, bag-type bioreactors like storage and mixing bags. It is mainly designed for cell culture applications but can also be used for monitoring microbial fermentation. The port is made of polyethylene which allows easy welding with the bags. A polymer optical fiber is attached to the port from the outside to read out the sensor. The Nice Port DO enables contactless measurements in culture bags, so there is no risk of contamination.
- Online dissolved O2 monitoring in single-use bioreactors
- Non-invasive measurements, no risk of contamination
- Easy integration by welding
- Pre-calibrated sensor
Pharma Industry: Oxygen Monitoring in Bags
Bags and single-use bioreactors are in the process of revolutionizing the way biopharmaceuticals are manufactured. Our non-invasive oxygen sensors are the tools to make the cultivation vessels fully disposable. As non-invasive pH sensors are also available, the two key parameters oxygen and pH can be controlled online.
|*after two-point calibration as described in the manual|
0 – 500 % air saturation0 – 1400 µmol/L
|Limit of detection||15 ppb|
± 0.05 % air saturation at 1 % air saturation
|Accuracy*||± 0.4 % O2 at 20.9 % O2|
± 0.05 % O2 at 0.2 % O2
|Drift||< 0.03 % O2 within 30 days (sampling interval of 1 min. / at 0 % oxygen)|
|Measurement temperature range||from 0 to + 50 °C|
|Response time (t90)||< 6 sec.|
|Compatibility||Aqueous solutions, ethanol, methanol|
pH 1 – 14
|Cross-sensitivity||Organic solvents, such as acetone, toluene, chloroform or methylene chloride|
|Sterilization procedure||Ethylene oxide (EtO)|
|Cleaning procedure||3 % H2O2|
Acidic agents (HCl, H2SO4), max. 4 – 5 %
|Calibration||Two-point calibration with oxygen-free environment (nitrogen, sodium sulfite) and air-saturated environment|
|Storage stability||24 months provided the sensor material is stored in the dark|
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