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Online Dissolved Oxygen Monitoring in Disposable Bioreactors

DO Nice Port

This port with integrated oxygen sensor is for customized application in flexible, bag-type bioreactors like storage and mixing bags. It is mainly designed for cell culture applications but can also be used for monitoring microbial fermentation. The port is made of polyethylene which allows easy welding with the bags. A polymer optical fiber is attached to the port from the outside to read out the sensor. The Nice Port DO enables contactless measurements in culture bags, so there is no risk of contamination.

  • Online dissolved O2 monitoring in single-use bioreactors
  • Non-invasive measurements, no risk of contamination
  • Easy integration by welding
  • Pre-calibrated sensor

Applications

Pharma Industry: Oxygen Monitoring in Bags

Bags and single-use bioreactors are in the process of revolutionizing the way biopharmaceuticals are manufactured. Our non-invasive oxygen sensors are the tools to make the cultivation vessels fully disposable. As non-invasive pH sensors are also available, the two key parameters oxygen and pH can be controlled online.


Technical

SpecificationsDissolved O2
*after two-point calibration as described in the manual
Measurement range

0 – 500 % air saturation

0 – 1400 µmol/L
Limit of detection15 ppb
Resolution

± 0.05 % air saturation at 1 % air saturation
± 0.5 % air saturation at 100 % air saturation
± 0.14 µmol/L at 2.83 µmol/L

± 1.4 µmol/L at 283.1 µmol/L
Accuracy*± 0.4 % O2 at 20.9 % O2
± 0.05 % O2 at 0.2 % O2
Drift< 0.03 % O2 within 30 days (sampling interval of 1 min. / at 0 % oxygen)
Measurement temperature rangefrom 0 to + 50 °C
Response time (t90)< 6 sec.
Properties
CompatibilityAqueous solutions, ethanol, methanol
No cross-sensitivity

pH 1 – 14
CO2, H2S, SO2
Ionic species

Cross-sensitivityOrganic solvents, such as acetone, toluene, chloroform or methylene chloride
Chlorine gas
Sterilization procedureEthylene oxide (EtO)
Gamma irradiation
Cleaning procedure3 % H2O2
Acidic agents (HCl, H2SO4), max. 4 – 5 %
CalibrationTwo-point calibration with oxygen-free environment (nitrogen, sodium sulfite) and air-saturated environment
Storage stability24 months provided the sensor material is stored in the dark

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