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Christopher J. Ochs, Junichi Kasuya, and Andrea Pavesi
GIT Laboratory Journal 2013, 7 - 8
Monitoring Cellular Oxygen Consumption Microfluidic devices fabricated from cyclic olefin copolymer (COC) and polydimethylsiloxane (PDMS) were combined with sensor foils to enable monitoring of oxygen tensions in the devices. The oxygen consumption of rat lung microvascular endothelial cells (EC) and rat hepatocytes (Hep) was numerically simulated and experimentally validated. The VisiSens system enables determining oxygen levels in the microfluidic devices and allows suggesting suitable culture device material depending on the application