The Smallest Devices Ensure Highest Productivity

Automated and compact bioprocess measurement systems that need only low sample volumes for analysis might save a lot of time and costs in the sustainable production of chemicals and pharmaceuticals. Therefore, the NANOBE project focused on the development of an analysis platform in nano- and micro-scale. It is composed of several "lap-on-chip" modules that can measure a broad range of analyte types including proteins, enzymes, RNA, metabolites, and entire cells. At the same time the flexible design of the measurement systems allows using only individual device components for analysis of specific compounds.
The chemical optical sensors by PreSens with their miniaturized size are ideally suited for integration in micro-measurement probes. Together with the iba, Heiligenstadt, Germany, a dead-volume free sampling probe for μL size had been constructed that allows in situ measurement of pH, oxygen and CO₂ in yeast and Streptomyces cell culture. Monitoring gas concentrations and pH inside the bioreactors in real-time is a huge advantage for feedback control, and optimization of culture conditions. The probe will be developed further and parts of the tubing-based fluidic network on the inside will be replaced by microfluidic devices.
The compact and versatile measurement system developed by the NANOBE project partners will be capable of rapid sample preparation and analysis and improve bioprocess development considerably.

Contact:

Christina Schlauderer
Communications
PreSens Precision Sensing GmbH
Phone: +49 941 27 21 09
E-Mail: christina.schlauderer@presens.de