Online pH monitoring in disposable bioreactors

pH Nice Port

This port with integrated sensor is for customized application in bioreactors or containers like storage and mixing bags. It is designed mainly for cell culture but can also be used for monitoring microbial fermentation. The port is made of polyethylene which allows easy welding with the bags. A color-coded polymer optical fiber is attached to the port from the outside to read out the sensor. The pH Nice Port enables contactless measurements in culture bags, so there is no risk of contamination.

  • Online pH monitoring in single-use bioreactors
  • Contactless measurements, no risk of contamination
  • Easy integration by welding
  • Pre-calibrated sensor
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Pharma Industry: pH Monitoring in Bags

Bags and single-use bioreactors are in the process of revolutionising the way biopharmaceuticals are manufactured. Our non-invasive pH sensors are the tools to make the cultivation vessels fully disposable. As non-invasive DO sensors are also available, the two key parameters oxygen and pH can be controlled online.


* exemplary values for sensors used without further handling in physiological solution; values may vary depending on integration procedure
** calibration and following measurements in the same conditions / system; equilibrated sensor kept in well stirred solution at 37 °C
*** recalibration may be required
Measurement range pH 5.5 - 8.5
Resolution at pH = 7: ± 0.01 pH
Accuracy** at pH = 7: ± 0.05 pH sensor spot calibration
at pH = 7: ± 0.10 pH sensor batch calibration
Drift at pH = 7: < 0.005 pH per day (sampling interval of 1 min.)
Measurement temperature range from + 5 to + 50 °C
Response time (t90)** < 120 sec.
Compatibility Aqueous solutions, ethanol (max. 10 % v/v), methanol (max. 10 % v/v), pH 2 - 10
Cross sensitivity Reduced to ionic strength (salinity); a high concentration of small fluorescent molecules in the visible range can interfere
Sterilization procedure*** Irradiation, Ethylene oxide (Et0)
Calibration Nice Ports are pre-calibrated; single-point calibration is recommended

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