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Online pH monitoring in disposable bioreactors

pH Nice Port

This port with integrated sensor is for customized application in bioreactors or containers like storage and mixing bags. It is designed mainly for cell culture but can also be used for monitoring microbial fermentation. The port is made of polyethylene which allows easy welding with the bags. A color-coded polymer optical fiber is attached to the port from the outside to read out the sensor. The pH Nice Port enables contactless measurements in culture bags, so there is no risk of contamination.

  • Online pH monitoring in single-use bioreactors
  • Contactless measurements, no risk of contamination
  • Easy integration by welding
  • Pre-calibrated sensor

Applications

Pharma Industry: pH Monitoring in Bags

Bags and single-use bioreactors are in the process of revolutionising the way biopharmaceuticals are manufactured. Our non-invasive pH sensors are the tools to make the cultivation vessels fully disposable. As non-invasive DO sensors are also available, the two key parameters oxygen and pH can be controlled online.


Technical

Specifications*
* exemplary values for sensors used without further handling in physiological solution; values may vary depending on integration procedure
** after single-point calibration at pH = 7
*** equilibrated sensor kept in well stirred solution at 37 °C
**** recalibration may be required
Measurement rangepH 5.5 - 8.5
Resolutionat pH = 7: ± 0.02 pH
Accuracy**at pH = 7: ± 0.05 pH
Driftat pH = 7: < 0.005 pH per day (sampling interval of 1 min.)
Measurement temperature rangefrom + 5 to + 50 °C
Response time (t90)***< 120 sec.
Properties
CompatibilityAqueous solutions, ethanol (max. 10 % v/v), methanol (max. 10 % v/v), pH 2 - 10
Cross sensitivityReduced to ionic strength (salinity); a high concentration of small fluorescent molecules in the visible range can interfere
Sterilization procedure****Irradiation, Ethylene oxide (Et0)
CalibrationNice Ports are pre-calibrated; single-point calibration is recommended

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