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Broader Range, Contactless pH Monitoring in Perfusion Systems
Single-Use pH Flow-Through Cell FTC-SU-LG1-US
The FTC-SU-LG1-US consists of a small pH sensor with broader measurement range - from pH 4.0 to 7.5 - on a color coded stick, which is attached to a single-use T-cell. The sensor stick can also be mounted to flow-through cells of other size and shape, according to requirements. Via polymer optical fiber the sensor inside the FTC can be read out non-invasively and pH changes in perfusion systems can be followed online. The FTC-SU-LG1-US is made of polycarbonate and is delivered untreated (not irradiated).
- Single-use flow-through cell
- Non-invasive, online pH measurements from pH 4.0 to 7.5
- No electrical interferences due to optical measurement
- Pre-calibrated, one-point calibration possible
- Different sizes and shapes for various flow rates
- Easy connection to external tubing
Applications
pH Monitoring in Liver Cell Bioreactor
An important aspect of efficient liver cell bioreactors is the automated regulation of physio-chemical culture parameters. A non-invasive pH regulation device for a perfusion bioreactor has been developed. The high performance of the system is based on one of our chemical optical flow-through cells for pH detection and its combination with precision mass-flow controllers for gas. The new controller allows long time stable and contamination free online pH regulation in complex bioreactor systems - an important technical contribution for future clinical applications.
Application Note by Marco Decker: pH Regulation for a Liver Cell Bioreactor
Online Measurement in Perfusion Systems
Beta-irradiated and pre-calibrated pH and DO flow-through sensors can be integrated into perfusion systems. This allows easy control of process parameters in perfusion reactors. Typically Luer connectors are used, though different sizes for larger or smaller flow rates are available.
Technical
| Specifications* | |
|---|---|
*provided pH sensors are used without further handling in physiological solutions | |
| Measurement range | 4.0 - 7.5 pH |
| Resolution | at pH = 6.5: ± 0.01 pH |
| Drift | at pH = 6: < 0.005 pH per day (sampling interval of 1 min.) |
| Measurement temperature range | from + 5 °C to + 50 °C |
| Response time (t90)** | < 120 sec. |
| Properties* | |
| Compatibility | Aqueous solutions, ethanol (max. 10 % v/v), methanol (max. 10 % v/v), pH 2 - 10 |
| Cross-sensitivity | Reduced ionic strength (salinity) |
| Sterilization procedure*** | Irradiation, Ethylene oxide (EtO) |
| Calibration | FTCs are pre-calibrated; single-point calibration is recommended |
| T-cell formats | Luer T-cell (delivered), inner diameter 5 mm, cell volume 0.3 mL; |
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FAQs
How do I import data into excel from a text file containing measurement data?
How does temperature affect my pH measurement?
How to prepare buffers of constant ionic strength and calibrate optical pH sensors?
What is the time of delivery?
Which buffers can be used for calibration of chemical optical pH sensors?
Which substances can interfere with the optical O2, pH and CO2 measurements?
Why does my pH sensor not work in tap water?