Online Monitoring in Perfusion Systems with Single-use Sensor

Single-Use pH Flow-Through Cell FTC-SU-HP5-S

A miniaturized optical pH sensor is attached to a color coded stick, which can be attached to flow-through cells of different size and shape, according to requirements. A polymer optical fiber connects the sensor inside the flow-through cell to the pH meter. The single-use T-cell of the FTC-SU-HP5-S is made of polycarbonate and all parts come beta-irradiated.

  • Single-use flow-through cell
  • Precise online monitoring of pH in perfusion systems
  • Different sizes and shapes for various flow rates
  • Easy connection to external tubing
  • Customized connectors are available, e. g. CPC
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pH Monitoring in Liver Cell Bioreactor

An important aspect of efficient liver cell bioreactors is the automated regulation of physio-chemical culture parameters. A non-invasive pH regulation device for a perfusion bioreactor has been developed. The high performance of the system is based on one of our chemical optical flow-through cells for pH detection and its combination with precision mass-flow controllers for gas. The new controller allows long time stable and contamination free online pH regulation in complex bioreactor systems - an important technical contribution for future clinical applications.

Application Note by Marco Decker: pH Regulation for a Liver Cell Bioreactor

Online Measurement in Perfusion Systems

Beta-irradiated and pre-calibrated pH and DO flow-through sensors can be integrated into perfusion systems. This allows easy control of process parameters in perfusion reactors. Typically Luer connectors are used, though different sizes for larger or smaller flow rates are available.


Measurement range 5.5 - 8.5 pH
Resolution at pH = 7: ± 0.01 pH
Accuracy** at pH = 7: ± 0.05 pH sensor spot calibration
at pH = 7: ± 0.10 pH sensor batch calibration
Drift at pH = 7: < 0.005 pH per day (sampling interval of 1 min.)
Measurement temperature range from + 5 to + 50 °C
Response time (t90)** < 120 sec.
Compatibility Aqueous solutions, ethanol (max. 10 % v/v), methanol (max. 10 % v/v), pH 2- 10
Cross-sensitivity Reduced to ionic strength (salinity); a high concentration of small fluorescent molecules in the visible range can interfere
Cleaning procedure*** Irradiation, Ethylene oxide (EtO)
Calibration FTCs are pre-calibrated; single-point calibration is recommended
T-cell formats Luer T-cell (delivered), inner diameter 5 mm, cell volume 0.3 mL;
1/4" x 1/4" (Qosina), cell volume 2.1 mL;
3/8" x 3/8" (Qosina), cell volume 4.6 mL;
1/2" x 1/2" (Qosina), cell volume 8.3 mL

* provided pH sensors are used without further handling in physiological solutions
** calibration and following measurements in the same conditions / system; equilibrated FTC with physiological solution and sufficient flow rate (min. 15 mL/min) at 37 °C
***recalibration may be required

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