Top

Single-use Sensor for Online pH Monitoring in Perfusion Systems

Single-Use pH Flow-Through Cell FTC-SU-LG1-S

The FTC-SU-LG1-S consists of a broad range pH sensor spot (pH 4.0 to 7.5) on a color coded stick, which is attached to a single-use T-cell. Via polymer optical fiber the sensor inside the FTC is read out non-invasively and pH changes in perfusion systems can be followed online. The FTC-SU-LG1-S is made of polycarbonate and is delivered beta-irradiated. Other cell formats (see technical data) are available on request.

  • Single-use flow-through cell
  • Non-invasive, online pH measurements from pH 4.0 to 7.5
  • No electrical interferences due to optical measurement
  • Pre-calibrated, one-point calibration possible
  • Different sizes and shapes for various flow rates
  • Easy connection to external tubing

Applications

pH Monitoring in Liver Cell Bioreactor

An important aspect of efficient liver cell bioreactors is the automated regulation of physio-chemical culture parameters. A non-invasive pH regulation device for a perfusion bioreactor has been developed. The high performance of the system is based on one of our chemical optical flow-through cells for pH detection and its combination with precision mass-flow controllers for gas. The new controller allows long time stable and contamination free online pH regulation in complex bioreactor systems - an important technical contribution for future clinical applications.

Application Note by Marco Decker: pH Regulation for a Liver Cell Bioreactor


Online Measurement in Perfusion Systems

Beta-irradiated and pre-calibrated pH and DO flow-through sensors can be integrated into perfusion systems. This allows easy control of process parameters in perfusion reactors. Typically Luer connectors are used, though different sizes for larger or smaller flow rates are available.


Technical

Specifications*
Measurement range4.0 - 7.5 pH
Resolution at pH = 6.5: ± 0.02 pH
Measurement temperature rangefrom + 5 °C to + 50 °C
Response time (t90)**< 120 sec.
Properties*
CompatibilityAqueous solutions, ethanol (max. 10 % v/v), methanol (max. 10 % v/v), pH 2 - 10
Cross-sensitivityReduced ionic strength (salinity)
CalibrationSSTs (sensor sticks) are pre-calibrated; single-point calibration is recommended
Storage stability18 months provided the sensor is stored in the dark
T-cell formats

Luer T-cell (delivered), inner diameter 5 mm, cell volume 0.3 mL;
1/4" x 1/4" (Qosina), cell volume 2.1 mL;
3/8" x 3/8" (Qosina), cell volume 4.6 mL;
1/2" x 1/2" (Qosina), cell volume 8.3 mL

*provided pH sensors are used without further handling in physiological solutions
**equilibrated FTC with physiological solution and sufficient flow rate (min. 15 mL/min) at 37 °C

Related products

pH-1 SMA LG1 compact fiber optic pH meter

pH-1 SMA LG1

This small pH meter can be set up almost anywhere. It is…

More
Polymer Optical Fiber POF with two SMA sockets

Polymer Optical Fiber POF

A polymer optical fiber (POF) is needed to transfer…

More

Presens TV

Watch tutorials, webinars and informative videos about PreSens optical sensor systems.

All videos