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Single-use Sensor for Online pH Monitoring in Perfusion Systems
Single-Use pH Flow-Through Cell FTC-SU-LG1-S
The FTC-SU-LG1-S consists of a broad range pH sensor spot (pH 4.0 to 7.5) on a color coded stick, which is attached to a single-use T-cell. Via polymer optical fiber the sensor inside the FTC is read out non-invasively and pH changes in perfusion systems can be followed online. The FTC-SU-LG1-S is made of polycarbonate and is delivered beta-irradiated. Other cell formats (see technical data) are available on request.
- Single-use flow-through cell
- Non-invasive, online pH measurements from pH 4.0 to 7.5
- No electrical interferences due to optical measurement
- Pre-calibrated, one-point calibration possible
- Different sizes and shapes for various flow rates
- Easy connection to external tubing
pH Monitoring in Liver Cell Bioreactor
An important aspect of efficient liver cell bioreactors is the automated regulation of physio-chemical culture parameters. A non-invasive pH regulation device for a perfusion bioreactor has been developed. The high performance of the system is based on one of our chemical optical flow-through cells for pH detection and its combination with precision mass-flow controllers for gas. The new controller allows long time stable and contamination free online pH regulation in complex bioreactor systems - an important technical contribution for future clinical applications.
Application Note by Marco Decker: pH Regulation for a Liver Cell Bioreactor
Online Measurement in Perfusion Systems
Beta-irradiated and pre-calibrated pH and DO flow-through sensors can be integrated into perfusion systems. This allows easy control of process parameters in perfusion reactors. Typically Luer connectors are used, though different sizes for larger or smaller flow rates are available.
|Measurement range||4.0 - 7.5 pH|
|Resolution||at pH = 6.5: ± 0.02 pH|
|Measurement temperature range||from + 5 °C to + 50 °C|
|Response time (t90)**||< 120 sec.|
|Compatibility||Aqueous solutions, ethanol (max. 10 % v/v), methanol (max. 10 % v/v), pH 2 - 10|
|Cross-sensitivity||Reduced ionic strength (salinity)|
|Calibration||SSTs (sensor sticks) are pre-calibrated; single-point calibration is recommended|
|Storage stability||18 months provided the sensor is stored in the dark|
Luer T-cell (delivered), inner diameter 5 mm, cell volume 0.3 mL;
| *provided pH sensors are used without further handling in physiological solutions|
**equilibrated FTC with physiological solution and sufficient flow rate (min. 15 mL/min) at 37 °C