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Plugs with Sensors for Microfluidic and Millifluidic Chips
O2 SensorPlug
The O2 SensorPlug by PreSens is specifically designed for millifluidic and microfluidic applications. With the appropriate chip and port design, SensorPlugs allow for online monitoring of O2 at one or several positions on your microfluidic device. An optical sensor is attached to e.g. a Mini Luer plug, which can easily be integrated in your chip via the corresponding port. A polymer optical fiber with 1 mm diameter connects the plug with an oxygen meter. The sensor is read out non-invasively, so there is no risk of contamination. SensorPlugs are delivered beta irradiated and pre-calibrated and you are ready to start your measurements right away.
We offer customized SensorPlug formats as well as support for chip and port design including the VisiSens 2D imaging system for preliminary evaluation of your chip. The O2 SensorPlugs can be combined with pH and CO2 SensorPlugs and measurements can be controlled from one PC via the PreSens Measurement Studio 2 software.
- Non-invasive O2 monitoring in millifluidic & microfluidic chips
- Pre-calibrated sensors, plug & play
- Beta irradiated
- Compatible with PMS2, standard PreSens O2 meters & EOMs
Applications
Cell Culture Microenvironment Monitoring
SensorPlugs offer the unique possibility to measure contactless directly inside the channel. This way the cells' undisturbed microenvironment can be monitored and investigated. Tumor cell research, the assessment of cell metabolism or cell signaling in organ-on-a-chip applications will profit from this information.
Reaction Monitoring in Microfluidics
Oxygen, pH and CO2 are important parameters in many chemical reactions. Direct monitoring in the microchannels can enable precise control of the reactions and deliver decisive information about reaction speed. Oxygen monitoring with SensorPlugs is a further step towards real Lab-on-a-Chip applications.
Technical
| Specifications | Gaseous & Dissolved O2 | Dissolved O2 |
|---|---|---|
| *after two-point calibration as described in the manual | ||
| Measurement range | 0 - 100 % O2 0 - 1000 hPa | 0 - 45 mg/L 0 - 1400 µmol/L |
| Limit of detection | 0.03 % oxygen | 15 ppb |
| Resolution | ± 0.01 % O2 at 1 % O2 ± 0.05 % O2 at 20.9 % O2 | ± 0.005 mg/L at 0.4 mg/L ± 0.025 mg/L at 9.06 mg/L |
| Accuracy at + 20 °C* | ± 0.05 % O2 or ± 3 % rel. | |
| Measurement temperature range | From 0 to + 50 °C | |
| Response time (t90) | < 6 sec. | < 40 sec. |
| Compatible O2 meters | OXY-1 ST (trace), OXY-4 ST (trace), Microx 4 (trace) | |
| Properties | ||
| Compatibility | Aqueous solutions, ethanol, methanol | |
| No cross-sensitivity | pH 1 - 14 CO2, H2S, SO2 Ionic species | |
| Cross-sensitivity | Organic solvents such as acetone, toluene, chloroform or methylene chloride Chlorine gas | |
| Cleaning procedure | Ethylene oxide (EtO), beta irradiation | |
| Calibration | Two-point calibration in oxygen-free environment (nitrogen, sodium sulfite) and air-saturated environment | |
| Storage stability | 60 months provided the sensor material is stored in the dark at room temperature | |
| Plug type | Male Mini Luer fluid connector; customized plug formats available on request | |
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Resources
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Development of Biomimetic Lung-on-a-Chip Platform
A Microfluidic Platform for Real-Time Non-Invasive Monitoring of Microglia Polarization
Microfluidic Approach for Measurements of pH, O2, and CO2 in Saliva
Microfludic Platform for Examination of Effect of Chewing Xylitol Gum on Salivary pH, O2, and CO2
Microfluidic Platform for Examination of Effect of Chewing Xylitol Gum on Salivary pH, O2, and CO2