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Online pH Monitoring in Microfluidic & Millifluidic Chips

pH SensorPlug

The pH SensorPlugs by PreSens enable online pH monitoring in millifluidic and microfluidic applications. With the appropriate chip and port design, the SensorPlugs can be integrated at one or several positions on your microfluidic device. An optical sensor is attached to an e.g. Mini Luer based plug, which can easily be integrated in your chip via the corresponding port. The plug is connected to a pH meter via a polymer optical fiber (1 mm diameter) and the sensor is read out non-invasively, so there is no risk of contamination. SensorPlugs are delivered beta irradiated and pre-calibrated so you can start your measurements right away. We offer customized SensorPlug formats as well as support for chip and port designs including the VisiSens 2D imaging system for preliminary evaluation of your chip. In order to obtain even more information about your process you can combine the pH SensorPlug with plugs for O2 and CO2 measurement. The monitoring with all SensorPlug types can be controlled from one PC with the PreSens Measurement Studio 2 software.

  • Non-invasive pH monitoring in millifluidic & microfluidic chips
  • Pre-calibrated sensors, plug & play
  • Beta irradiated
  • Compatible with PreSens Measurement Studio2, standard PreSens pH meters and EOMs

Applications

Cell Culture Microenvironment Monitoring

SensorPlugs offer the unique possibility to measure contactless directly inside the channel. This way the cells' undisturbed microenvironment can be monitored and investigated. Tumor cell research, the assessment of cell metabolism or cell signaling in organ-on-a-chip applications will profit from this information.


Reaction Monitoring in Microfluidics

Oxygen, pH and CO2 are important parameters in many chemical reactions. Direct monitoring in the microchannels can enable precise control of the reactions and deliver decisive information about reaction speed. Oxygen monitoring with SensorPlugs is a further step towards real Lab-on-a-Chip applications.


Technical

Specifications*
*provided the pH SensorPlugs are used without further handling in physiological solutions
**equilibrated sensor kept in well stirred solution at + 37 °C
Measurement rangepH 5.5 - 8.5
ResolutionAt pH = 7: ± 0.01 pH
AccuracyAt pH = 7: ± 0.05 pH (sensor spot calibration)
Measurement temperature rangeFrom 0 to + 50 °C
Response time (t90)**< 120 sec.
Compatible pH meterspH-1 SMA HP5 with SMA-ST-Adapter
Properties
CompatibilityAqueous solutions, ethanol (max. 10 % v/v), methanol (max. 10 % v/v), pH 2 - 10
Cross-sensitivityReduced to ionic strength (salinity); a high concentration of small fluorescent molecules in the visible range can interfere
Cleaning procedurepH SensorPlugs are delivered beta-irradiated; a second irradiation or autoclaving is not recommended
CalibrationpH SensorPlugs are pre-calibrated
Storage stability18 months provided the sensor material is stored in the dark
Plug typeMale Mini Luer fluid connector; customized plug formats available on request

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