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OEM components by PreSens are integrated in customized monitoring systems in medical equipment and life science research. Single-use flow-through cells enable online monitoring in perfusion systems during surgeries.

Medical Research & Life Sciences

Our most recent business field arose from a cooperation with renowned medical technology manufacturers from the Medical Devices sector. PreSens supplies OEM parts, which are integrated into more complex medical systems or multisensory tools for high throughput analyses. Our microsensors, sensor spots, and imaging systems are already applied for high precision measurements in tissue engineering, microfluidics, and many other research fields in medical research and the life sciences.

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O2 Monitoring in Tissue Engineering & Regenerative Medicine

One main issue in 3D engineered tissue is the development of oxygen and nutrient gradients towards the middle of an engineered tissue. With PreSens microsensors high resolution measurements inside the tissue can be performed. Our micromanipulator systems ensure exact localization of the measurement tip within a sample. With optical sensor foils integrated at the bottom of the tissue culture vessel 2D analyte maps can be recorded and gradient development can be followed over time.

Gradients and Oxygen Consumption in Microfluidics

Microfluidics are more and more applied to study cell signaling or metabolic processes in microenvironments as they require minimal resources. Optical sensors are an ideal tool to monitor culture conditions even at this small scale. For measurements at the in- and outlet flow-through cells with integrated sensors for very small volumes are available. Moreover, the VisiSens™ imaging system offers complete new opportunities as whole chip areas can be monitored over time.

Monitoring O2 Supply & pH in Transplantation Research

The time available for transplanting organs or tissue is strongly limited, as the transplants are separated from nutrient and oxygen supply. Researchers investigate new methods for sustaining tissue and organs over longer time spans and reduce the risk of apoptosis or even necrosis. Due to their versatile design PreSens optical sensors are already applied for monitoring oxygen supply and pH of perfusates in different transplantation research projects.

Optical Measurements in High Throughput Analysis

Optical sensors for online oxygen and pH measurements can be integrated in disposable culture vessels. The small sensor size does not disturb media flow or cause shear stress. With multi-channel read-out systems they are ideal tools for conducting highly parallelized measurements and online monitoring in screening application. There are systems available from mL up to several liters scale.

Tumor Research

Recent research suggests that processes in the tumor microenvironment can influence its growth and development. In vivo experiments on tumor microenvironments are challenging and precise measurement devices are needed. PreSens microsensors with a tip size thinner than a hair combined with our micromanipulators allow to conduct most accurate on-the-spot measurements inside tissue. Even 2-dimensional assessment of analyte distributions over cross-sections of tumor tissue can be realized with the VisiSens™ imaging system.

Quality Control in Pharmaceuticals

PreSens offers several sensor solutions for quality control that contribute to ensure the safety of oxygen-sensitive pharmaceuticals. Whether it is monitoring inside liquids after the filling process, experiments to ensure the air tightness of closures, or headspace measurements in blisters and vials, PreSens optical sensors offer the ideal tools for checks and shelf life determination, ensuring the product quality with fast and precise measurements.

Minimally Invasive Brain Sensor

PreSens supplies sensors and transmitters to medical device manufacturers and supports necessary qualification / certification for medical use. Our microsensors are miniaturized fluorescence sensors. The optical oxygen microsensors are based on a 140 µm silica fiber and are available with two different sensor tip diameters, a < 50 µm tapered tip and a 140 µm flat-broken tip. Other potential applications include tumor oxygen monitoring/angiogenesis; vital organ and muscle tissue monitoring; flap monitoring as well as ophthalmology.

Blood Perfusion Monitoring

The cardiac surgeon benefits from the extraordinary fast sensor response and the precise pO2 reading. The flexible nature of the sensor spots supports a free design of the perfusion cell. Sensor spots can be sterilized by autoclavation, irradiation, or ETO. The integrated sensor spots can also be delivered pre-calibrated.

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