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Micro-invasive Measurements with Sensor Tips Thinner than a Hair

Needle-Type Oxygen Microsensor NTH-PSt1

This sensor is a miniaturized optical oxygen sensor designed for all research and packaging applications where a small tip size (< 50 µm tapered sensor tip TS, < 140 μm flat-broken sensor tip TF) and fast response time (t90 < 3 s) are necessary. It is mounted inside a stainless steel needle, which protects the optical fiber and oxygen-sensitive sensor tip. This design is optimal for easy penetration of tissue, septum rubber or packaging materials. After penetration the sensor tip is extended for measurements.

  • High spatial resolution (down to < 50 μm)
  • High temporal resolution (t90 < 3 sec.)
  • No consumption of oxygen
  • Signal independent of flow velocity
  • Measures in liquids as well as in gas phase

Applications

Packaging & Quality Control

Oxygen inside packaging can lead to oxidative deterioration of certain products. Therefore, determination of the oxygen content within packages or pharmaceutical vials is of essential importance to ensure both the filling quality and the long-term storage stability. With our micro-invasive needle-type oxygen microsensors we offer a simple tool to determine residual oxygen both in the headspace and in liquids. The septum of the vial or package is pierced with the needle and the sensor is extended for measurement. As the measurement is made inside the package no error-prone and time consuming sampling is necessary. These oxygen microsensors are ideal tools for quality control in the food & beverage, packaging, and pharmaceutical industries.


Tissue Engineering

Oxygen microsensors measure the oxygen content in various volume compartments of the tissue engineering constructs. To do so, hair-thin sensors are inserted into the constructs and the oxygen content is measured online. In this way, the oxygen partial pressure is measured with a high local resolution and correlated with the constructs tissue quality (composition of the extracellular matrix).


Technical

SpecificationsGaseous & Dissolved O2Dissolved O2
*after two-point calibration as described in the manual
**TS: tapered sensor tip with a diameter < 50 μm and no optical isolation
***TF: flat-broken sensor tip with a diameter of 140 μm
Measurement range

0 – 50 % O2

0 – 500 hPa

0 – 22.5 mg/L

0 – 700 µmol/L
Limit of detection0.05 % oxygen20 ppb
Resolution

± 0.01 % O2 at 0.21 % O2
± 0.09 % O2 at 20.9 % O2
±0.1 hPa at 2 hPa

± 1 hPa at 207 hPa

± 0.005 mg/L at 0.09 mg/L
± 0.04 mg/L at 9.06 mg/L
± 0.14 µmol/L at 2.83 µmol/L

± 1.3 µmol/L at 283 µmol/L
Accuracy*± 0.4 % O2 at 20.9 % O2
± 0.05 % O2 at 0.2 % O2
Drift< 0.1 % O2 within 30 days (sampling interval of 1 min.)
Measurement temperature rangefrom 0 to + 50 °C
Response time TS** (t90)< 1 sec. (gas)< 2 sec. (liquid)
Response time TF*** (t90)< 15 sec. (gas)< 30 sec. (liquid)
Properties
CompatibilityAqueous solutions, ethanol, methanol
No cross-sensitivity

pH 1 – 14
CO2, H2S, SO2
Ionic species

Cross-sensitivityOrganic solvents, such as acetone, toluene, chloroform or methylene chloride
Chlorine gas
Sterilization procedure

Ethylene oxide (EtO)

Cleaning procedure3 % H2O2
Ethanol
Soap solution
CalibrationTwo-point calibration with oxygen-free environment (nitrogen, sodium sulfite) and air-saturated environment
Storage stability60 months provided the sensor material is stored in the dark at room temperature

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Resources

Publications

Oxygen Consumption of Crayfish under Different Temperature Regimes Alginate-based Bi-layered Hydrogels with Embedded Cells for the Regenerative Therapy of Osteo-chondral Defects Hypoxic Preconditioning of Human Mesenchymal Stem Cells Hypoxia in Static and Dynamic 3D Culture Systems New mL-Scale Bioreactor for the Cultivation of Mycelium Forming Microorganisms Hydrogels as Cell Carriers for Tissue Engineering Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status O2-controllable hydrogels for studying cellular responses to hypoxic gradients in three dimensions in vitro and in vivo Intratumoral oxygen gradients mediate sarcoma cell invasion Entrapped Sediments as a Source of Phosphorus in Epilithic Cyanobacterial Proliferations in Low Nutrient Rivers Contrasting habitats but comparable microbial decomposition in the benthic and hyporheic zone More than just CO2-recycling: corticular photosynthesis as a mechanism to reduce the risk of an energy crisis induced by low oxygen Seed Coating Increases Seed Moisture Uptake and Restricts Embryonic Oxygen Availability in Germinating Cereal Seeds Energy Status and Its Control on Embryogenesis of Legumes. Embryo Photosynthesis Contributes to Oxygen Supply and Is Coupled to Biosynthetic Fluxes The effects of sustained exercise and hypoxia upon oxygen tensions in the red muscle of rainbow trout Functional Groups and Activities of Bacteria in a Highly Acidic Volcanic Mountain Stream and Lake in Patagonia, Argentina Thermal physiology of the common eelpout (Zoarces viviparus) A simple method to measure effective catalase activities: Optimization, validation, and application in green coffee Xylem sap flow as a major pathway for oxygen supply to the sapwood of birch (Betula pubescens Ehr.) The interrelated effects of body size and choroid rete development on the ocular O2 partial pressure of Atlantic (Gadus morhua) and Greenland cod (Gadus ogac) Methodology and Significance of Microsensor-based Oxygen Mapping in Plant Seeds - an Overview Differences in the Bioenergetic Response of the Isolated Perfused Rat Heart to Selective ß1- and ß2-Adrenergic Receptor Stimulation Thermal sensitivity of cellular energy budgets in some Antarctic fish hepatocytes Physiological adaptations to high intertidal life involve improved water conservation abilities and metabolic rate depression in Littorina saxatilis The role of aerobic metabolism and intragel oxygen in hypoxia tolerance of three ctenophores: Pleurobrachia bachei, Bolinopsis infundibulum and Mnemiopsis leidyi A new microcosm to investigate oxygen dynamics at the sea ice water interface Effect of elevated temperature on aerobic respiration of coral recruits Flagellate and ciliate distribution in sediments of a lowland river: relationships with environmental gradients and bacteria Effects of Carex rostrata on soil oxygen in relation to soil moisture Effect of nutrient availability on carbon and nitrogen incorporation and flows through benthic algae and bacteria in near-shore sandy sediment Metabolic performance and survival of medusae in estuarine hypoxia A novel approach to the in situ measurement of oxygen concentrations in the sapwood of woody plants Oxygen-Mediated Regulation of Biofilm Development Is Controlled by the Alternative Sigma Factor in Staphylococcus epidermidis Effect of aerial O2 partial pressure on bimodal gas exchange and air-breathing behaviour in Trichogaster leeri Measurement of temperature and salinity effects on oxygen consumption of Artemia franciscana K., measured using fibre-optic oxygen microsensors Intragel oxygen promotes hypoxia tolerance of scyphomedusae Micro-optodes in sea ice: a new approach to investigate oxygen dynamics during sea ice formation Energy budget of hepatocytes from Antarctic fish (Pachycara brachycephalum and Lepidonotothen kempi) as a function of ambient CO2: pH-dependent limitations of cellular protein biosynthesis? Gradients of lipid storage, photosynthesis and plastid differentiation in developing soybean seeds Functions of straw for in situ remediation of acidic mining lakes Cadmium-dependent oxygen limitation affects temperature tolerance in eastern oysters (Crassostrea virginica Gmelin) Benthic Oxygen Consumption and Organic Matter Turnover in Organic-poor, Permeable Shelf Sands Causative role of oxidative stress in a Drosophila model of Friedreich ataxia Active brood care in Cancer setosus (Crustacea: Decapoda): the relationship between female behaviour, embryo oxygen consumption and the cost of brooding Embryogenesis and oxygen consumption in benthic egg clutches of a tropical clownfish, Amphiprion melanopus (Pomacentridae) NirS-containing denitrifier communities in the water column and sediment of the Baltic Sea Optimizing the Production of Bacterial Cellulose in Surface Culture: Evaluation of Substrate Mass Transfer Influences on the Bioreaction (Part 1) Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of oblob and dietary obese mice Temperature-dependent stress response in oysters, Crassostrea virginica: Pollution reduces temperature tolerance in oysters Response of Aquatic Leaf Associated Microbial Communities to Elevated Leachate DOC: A Microcosm Study The role of singlet oxygen and oxygen concentration in photodynamic inactivation of bacteria Degradation and mineralization of coral mucus in reef environments Hypoxic life of intertidal acorn barnacles Saving by freezing? Metabolic rates of Adamussium colbecki in a latitudinal context Development, Parallelization and Automation of a Gas-Inducing Milliliter-Scale Bioreactor for High-Troughput Bioprocess Design (HTBD) Rapid Depletion of Dissolved Oxygen in 96-Well Microtiter Plate Staphylococcus epidermidis Biofilm Assays Promotes Biofilm Development and Is Influenced by Inoculum Cell Concentration Essential fatty acids influence metabolic rate and tolerance of hypoxia in Dover sole (Solea solea) larvae and juveniles Sulfide-iron interactions in domestic wastewater from a gravity sewer New Milliliter-Scale Stirred Tank Bioreactors for the Cultivation of Mycelium Forming Microorganisms Effective diffusion and microbiologic activity as constraints describing pyrite oxidation in abandoned lignite mines Rising groundwater tables in partly oxidized pyrite bearing dump-sediments: Column study and modelling approach Differences in rhizome aeration of Phragmites australis in a constructed wetland Oxygen requirements of zebrafish (Danio rerio) embryos in embryo toxicity tests with environmental samples Online oxygen measurements in ex vivo perfused muscle tissue in a porcine model using dynamic quenching methods Migration capacity and viability of human primary osteoblasts in synthetic three-dimensional bone scaffolds made of tricalciumphosphate Neutralization by Metal Ions of the Toxicity of Sodium Selenide Symbiotic Leghemoglobins Are Crucial for Nitrogen Fixation in Legume Root Nodules but Not for General Plant Growth and Development Bark and woody tissue photosynthesis: a means to avoid hypoxia or anoxia in developing stem tissues In situ metabolism in halite endolithic microbial communities of the hyperarid Atacama Desert

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